In the early phase of cerebral ischemia, the levels of intracellular Ca++ and extracellular K+ are markedly increased in the ischemia area; subsequently, this leads to NKCC1-mediated Na+, K+, and Cl− transport and accompanying water influx into brain cells, leading to astrocytic swelling, cytotoxic edema, and cerebral infarction [9, 10]. Here, SLC12A2 is linked to ischemia.