In addition, nonsynonymous somatic mutations in the five familial family probands and the three patients with sporadic LC shared the same trends in enriched pathways; that is, the “Pathways in Cancer” or “PI3K/AKT Pathway” appeared in the top 10 KEGG pathways (Supplementary Table S6B). The gene discussed is AKT1; the disease is laryngotracheoesophageal cleft.