GCK and obesity due to melanocortin 4 receptor deficiency: Perinatal and/or chronic exposures to environmental doses of BPA are associated with changes in liver DNA methylation and expression of genes involved in energy metabolism (Carnitine palmitoyltransferase: Cpt1a, Sterol regulatory-element binding protein-1c: Srebp1c, Fatty acid synthase: Fas, Glucokinase: Gck, Nuclear factor E2-related factor 2: Nrf2 and Obesity-associated mesoderm-specific transcript: MEST) in rodents and humans [34–38].