Suppression of IRAK-1 in these animals prevented lupus nephritis suggesting IRAK-1 is a downstream target of the regulatory action of ABIN1 in the NF-κB signaling pathway and perturbation of IRAK-1 expression may counteract the inhibitory action of ABIN1 in NF-κB activation (Nanda et al. 2016). The gene discussed is IRAK1; the disease is lupus nephritis.