In addition, we verified the histological levels of SMG5, EZH2, FBLL1, ZNF239, and IGF2BP3 using the Human Protein Atlas database, and the results showed that EZH2 and IGF2BP3 were upregulated in HCC tissues and downregulated in normal tissue (Fig. 9e, f). The gene discussed is SMG5; the disease is hepatocellular carcinoma.