Depletion of CD11c+ cells in a mouse model of acute MI led to deterioration of LV function and remodeling,24 while a recent study depleting DC via the transcription factor Zbtb46 reduced infarct size, improved systolic function, and reduced CD3+ T cell numbers in the ischemic tissue.25 Human data are scarce and largely based on the presence or absence of DC in selected tissues. The gene discussed is ITGAX; the disease is myocardial infarction.