EGFR and non-small cell lung carcinoma: The aim of this study was to compare three methodologies that are based on targeted approaches: the QuantStudio 3D Digital PCR, the Scorpion-ARMS EGFR Plasma RGQ PCR Kit, and the PNAClamp EGFR. We applied these three platforms to detect cftDNA EGFR mutations in the plasma of EGFR-TKI treated patients with advanced NSCLC, at baseline and serially during the treatment.