In this study, we reported a performance comparison between three technologies (Scorpion-ARMS EGFR Plasma RGQ PCR Kit-QIAGEN, QuantStudio 3D Digital PCR System-Thermo Fisher Scientific and PNAClamp EGFR-PANAGENE) in detecting clinically-relevant EGFR mutations in tumor tissue and plasma collected from NSCLC patients. This evidence concerns the gene EGFR and neoplasm.