CCL2 and colorectal cancer: Akt activation by phosphatidylinositol phosphate kinase gamma (PIPKIγ)-mediated STAT3 phosphorylation induces CCL2 expression in colorectal cancer cells and silencing PIPKIγ greatly decreases CCL2 expression at both the mRNA and protein levels, leading to reduced chemotaxis of cancer cells to macrophages [33].