They may be resumed into a unitary approach known as amyloid hypothesis in AD, encompassing beta amyloid (Aβ) formation from APP precursor [6], Aβ aggregation in the amyloid cascade from toxic oligomers to senile plaques [7], tau protein aggregation [8], and tau hyperphosphorylation [9] as potential therapeutic targets. Here, MAPT is linked to Alzheimer disease.