Alteration in the expression level in isolated exosomes of patients with PC was reported for proteins CD63 (3.17 fold) and Rab5 (1.73 fold), and some miRNAs (>1.5 fold-change for hsa-miR-130a, hsa-miR-29b, hsa-miR-30b, hsa-miR-518d, hsa-miR-551b, and hsa-miR-646, and <0.67 fold-change for hsa-miR-601, hsa-miR-106b, hsa-miR-92a, hsa-miR-1275, and hsa-miR-302c*). This evidence concerns the gene CD63 and pachyonychia congenita.