The effects of such signals on tumor cell in terms of T cell- or natural killer cell-mediated lysis by RT involve major histocompatibility complex class I (MHC-I) [39,40], natural killer cell receptor NKG2D ligands, tumor necrosis factor receptor superfamily (TNFRSF) members, immune checkpoint molecules, and others. This evidence concerns the gene KLRK1 and neoplasm.