The expression of sterol regulatory element-binding protein 1 (SREBP-1), fatty acid synthase (FAS), and stearoyl-CoA desaturase-1 (SCD-1), which promote DNL in liver tissues, were significantly higher in the HF group compared with the HC group, indicating that the high-fructose diet increased the DNL in liver tissue (Figure 6). This evidence concerns the gene FASN and hydrops fetalis.