ERBB2 and breast neoplasm: We further found that S100A10 levels were significantly increased in high histologic grade tumors compared with normal mammary tissues (p < 0.01) and low grade tumors (p < 0.05) (Figure 7C) Among the molecular subtypes, S100A10 mRNA levels were significantly higher in triple negative (TN) and human epidermal growth factor receptor 2 (HER2)-enriched breast tumors compared to normal breast tissues.