The adipose tissue of individuals with obesity becomes highly inflamed and causes vascular dysfunction through greater secretion of vasoconstrictors, including via the renin-angiotensin-aldosterone system, superoxide, and proinflammatory adipokines, which are important contributors to endothelial activation, vascular inflammation, and neointimal formation [24]. The gene discussed is REN; the disease is obesity due to melanocortin 4 receptor deficiency.