PTK2 and malignant colon neoplasm: Matrix stiffening also mediates the upregulation of ISC markers (CD133, ALDH-1 and LGR5) in HCT116 human colorectal cancer cells [116] and increases the production of MMP-7 in the T84 colon cancer cell line [117], both through the activation of the Yes-associated protein (YAP) and integrin β1/focal adhesion kinase (FAK) pathways.