Normally, the membranous E-cadherin/β-catenin complex maintains the intercellular tight junction and minor free β-catenin cytoplasmic molecules are controlled by multiprotein complexes, while on the other hand, nuclear localization of β-catenin is essential for the progression of various human cancers, such as nasopharyngeal carcinoma, via transcriptional upregulation of downstream genes [30]. Here, CDH1 is linked to cancer.