AKT1 and neoplasm: More specifically, it has been highlighted that tumor suppressors that negatively regulate mTOR, (PTEN, AMPK, LKB1, and TSC1/2) initiate autophagy while mTOR activators (such as AKT, class I PI3K, Ras, inhibit autophagy, suggesting that autophagy may have a crucial role in tumor evolution [74].