ABCB1 and endocervical adenocarcinoma: Complementing this finding, using confocal microscopy and lysosomal fractionation, Yamagishi and colleagues observed a sizable reduction in lysosomal entrapment of doxorubicin and remarkable increase in nuclear localization of doxorubicin in resistant endocervical adenocarcinoma KBV1 cells upon application of P-glycoprotein inhibitor and genetic knockdown of p-glycoprotein [120].