Therefore, following doxorubicin deposition into the lysosomes, uptake of Dp44mT and DpC leads to potent apoptotic cell death through inducing ROS that eventually disintegrates lysosomal membrane in p-glycoprotein-over-expressing cancer cells, allowing doxorubicin to be re-localized to the nucleus and execute its cytotoxic effects [124]. Here, ABCB1 is linked to cancer.