LAMP1 and neoplasm: LAMP2, which, as with LAMP1, predominantly acts as a barrier against lysosomal membrane proteolysis in non-cancerous settings, can also be mobilized to the plasma membrane during early-stage tumor formation where insufficient blood vessel infiltration to the site of tumor induces hypoxic and acidic tumor microenvironment, as a cytoprotective mechanism helping tumor cells withstand chronic acidosis [99].