ABCB1 and cancer: For instance, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) and the clinically trialed di-2-pyridylketone 3-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) have been identified as substrates of lysosomal p-glycoproteins and subsequently induce LMP in p-glycoprotein-overexpressing cancer cells.