LAMP1 and cancer: To favor cell survival and circumvent cell death, cancer cells stringently upregulate lysosome associated membrane protein-1 and 2 (LAMP1 and LAMP2), both of which collectively account for approximately half of the lysosomal membrane proteins and safeguard the lysosomal membrane integrity through forming heavily glycosylated membrane barriers encapsulating the acidic luminal lysosomal environment from the cytosol [95].