We had initially hypothesized that many of these isolates would be CXCR4-using strains since the participants are at an advanced stage of HIV infection as shown by the presence of CM and low CD4+ T-cell count; however, a high number of CCR5-using strains were observed in both compartments with no statistically significant difference in the proportion of CCR5-using strains in plasma and CSF (p = 0.5). Here, CXCR4 is linked to HIV infectious disease.