As for HHV-6, EBV infection also reduces autophagy in infected monocytes, leading to p62/SQSTM1 accumulation and Nuclear factor erythroid 2-Related Factor 2 (NRF2) up-regulation, preventing ROS increase induced by Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and Interleukin-4 (IL-4). The gene discussed is IL4; the disease is Epstein-Barr virus infection.