In this pilot study, we aimed to (1) evaluate the significance of apoE genotypes as the risk factors of CVD in RA patients; (2) examine the differences in the plasma lipid profile, plasma adipokines levels, IR, and inflammatory parameters in RA patients with different apoE genotypes; and (3) evaluate the association of plasma adipokines levels with lipid profile, IR, RA inflammatory parameters, and CVD risk in RA patients with different apoE genotypes. The gene discussed is APOE; the disease is rheumatoid arthritis.