CRP and Cowden syndrome 1: The previous study on nonanimal CS included only C-reactive protein (CRP) blood levels, the most commonly investigated systemic inflammation marker, easy to assess in clinical practice, but it did not assess other important markers of inflammation (such as cytokines) or markers of cartilage catabolism (i.e., collagen type II, CTX-II) or synovium metabolism (i.e., hyaluronic acid) and markers of oxidative stress.