As mentioned above, a recent study demonstrated that iPSC-derived astrocytes from familial mutant LRRK2 G2019S PD patients exhibited dysfunctional chaperone-mediated autophagy, impaired macroautophagy, and progressive α-synuclein accumulation, which caused dopaminergic neurodegeneration [113]. The gene discussed is LRRK2; the disease is Parkinson disease.