Apart from them, many other molecules such as Glypican 3 (GPC-3), Alpha-l fucosidase (AFU), Golgi protein-73 (GP73) and Squamous cell carcinoma antigen (SCCA), or tumor-associated signatures such as DNA mutation, DNA methylation, micro-RNAs (miRNAs) and long non-coding RNAs (lncRNAs) are under investigation that could be taken into consideration for future clinical practice. The gene discussed is GPC3; the disease is neoplasm.