In a meta-analysis study comparing the efficacy of ultrasound with or without AFP for early HCC detection (n = 2770), Kristina Tzartzeva et al. showed that the use of AFP in combination with abdominal ultrasound can significantly increases the sensitivity of early HCC detection as compared to ultrasound alone (63% vs. 45%) [28]. This evidence concerns the gene AFP and hepatocellular carcinoma.