AFP and hepatocellular carcinoma: In a large cohort study involving more than 4200 serum samples derived from healthy individuals and patients with benign or malignant liver disease, the sensitivity (74.6% for GP73 vs. 58.25% for AFP) and specificity (97.4% for GP73 vs. 85.3% for AFP) of GP73 for detection of HCC were higher than AFP [50].