ARRB2 and chronic myelogenous leukemia, BCR-ABL1 positive: When HSC-enriched populations were isolated from ARRB2 depleted mice and transduced with the p210 form of the BCL-ABL fusion oncogene for recapitulation of CML in mice, they failed to establish CML in 93% of wild-type recipient mice, suggesting that ARRB2 plays a key role in initiation of CML [16].