Together with isoform-specific changes in AQP4 localization and redistribution of AQP4 in high-grade astrocytomas, mislocalization of inwardly rectifying K+ channel Kir4.1 was detected in low- and high-grade astrocytomas and oligodendrogliomas [72]. The gene discussed is AQP4; the disease is astrocytoma (excluding glioblastoma).