Cancer cells secrete many inflammation mediators including nuclear factor kappa-light-chain-enhancer of activated B cells, tumor necrosis factor-a, interleukin-1, and interleukin-6 that have been shown to increase the metabolic expenditure through the activation of thermogenesis, inhibit differentiation of muscle and adipose tissues, and cause loss of appetite [84,85,86]. This evidence concerns the gene TNF and cancer.