While expression of the MYC family members MYC, MYCL, and MYCN is frequently upregulated in human SCLC, tumors in RP mice with overexpression of Mycl do not have high levels of NFIB, suggesting this may be a mechanism specific to MYC (Sos et al, 2012; Semenova et al, 2016). The gene discussed is NFIB; the disease is small cell lung carcinoma.