Previous studies of SCLC brain metastases have described upregulation of angiogenesis‐related factors, with some, such as PDGFRB and ANGPTL4, specifically upregulated in SCLC brain metastases compared to those from NSCLC and melanoma (Ilhan‐Mutlu et al, 2016). This evidence concerns the gene ANGPTL4 and small cell lung carcinoma.