YWHAQ and Alzheimer disease: Second, according to the cascading network failure and the prion‐like propagation models of misfolded beta amyloid and tau proteins (Jones et al., 2016; Ossenkoppele et al., 2019; Raj, Kuceyeski, & Weiner, 2012; Vogel et al., 2020; Zhou, Gennatas, Kramer, Miller, & Seeley, 2012), AD brain alterations are theorized to spread from the DMN to multimodal functional hubs of the brain network, including salience and executive regions (Crossley et al., 2014; Mišić et al., 2015).