In some instances, tailored therapy attempts with immunotherapeutics or tyrosine kinase inhibitors are used, e.g., trastuzumab in HER2-positive breast cancer or gastric cancer, imatinib in Philadelphia chromosome-positive chronic myeloid leukemia (Ph + CML), BRAF-directed therapy with vemurafenib or dabrafenib/trametinib in melanoma [12–14]. The gene discussed is ERBB2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.