Moreover, reduced expression of TSC2 was also found to be associated with shorter disease-free survival among 50 patients with CRC.46 Notably, TSC2 was shown to positively regulate expression of mucin2, a marker of goblet cell differentiation in intestinal cells.47,48 TSC2 inactivation altered differentiation throughout the intestinal epithelium, with a marked decrease in goblet cell lineages.49 As goblet cell carcinoid tumors accounted for less than 10% of cases in this cohort, we were unable to assess genomic differences of AC by age at disease onset specific to this histological subtype. The gene discussed is TSC2; the disease is goblet cell carcinoma.