Similarly, for patients with non-mucinous appendiceal adenocarcinomas, young individuals had 72% decreased odds of presenting with GNAS variations compared with late-onset cases, although these findings were not statistically significant (OR, 0.28; 95% CI, 0.07-1.14; P = .08) (eTable 3 in the Supplement). Here, GNAS is linked to appendix adenocarcinoma.