In our experiment, propofol‐induced apoptosis of hippocampal neurons and expression of caspase‐3 were inhibited with the treatment of RTA 408 with the decreased loss of NeuN (+) and Map2 (+) principal cells, PV(+) interneurons, and CaMKII (+) pyramidal neurons in the hippocampal CA1 areas of mice, indicating that RTA 408 may play a protective role in propofol‐induced cognitive impairment. Here, MAP2 is linked to Cognitive impairment.