2015). Oral administration of crocin (100 and 200 mg/kg b.w.)significantly decreased elevated levels of cyclooxygenase-2 (COX-2) and iNOS in diethylnitrosamine (DEN) induced hepatocellular carcinoma in male albino Wistar rats (Amin et al. 2016). Here, PTGS2 is linked to hepatocellular carcinoma.