Treated monocytes (1 × 106 cells/mL) of both healthy donors and Alzheimer’s disease (AD) subject with a constituent of C. sativus,trans-crocetin (5, 10, 25, 50, 100, and 150 μM) enhanced amyloid-β 42 (Aβ42) degradation in AD monocytes through the up-regulation of the lysosomal protease cathepsin B (Tiribuzi et al. The gene discussed is CTSB; the disease is early-onset autosomal dominant Alzheimer disease.