2013). Furthermore, kaempferol (5–20 μM) significantly reduces vascular endothelial growth factor (VEGF) gene expression at mRNA and protein levels and significantly inhibited angiogenesis and tumour growth. Moreover, kaempferol treatment, down-regulated HIF-1α (a regulator of VEGF) dose dependently in ovarian cancer cell line (Luo et al. 2009). This evidence concerns the gene HIF1A and neoplasm.