The Western blotting results (Figure 1A‐G) showed that AS‐IV inhibited the release of NLRP‐3 inflammatory bodies and calpain‐1 in the pulmonary tissues of rats with pulmonary hypertension, and the inhibitory effect was similar to that of MCC950 and MDL28170. The gene discussed is NLRP3; the disease is pulmonary arterial hypertension.