DYRK1A and pancreatic insulinoma: To address whether the transcriptional signature of β-cell replication observed in mice is modeled on replication process of human pancreatic β-cells, we compared to human insulinoma (Wang et al., 2017), Dyrk1a inhibitor-induced β-cell replication (Ackeifi et al., 2020), and juvenile human islets (Arda et al., 2016).