DRD2 and schizophrenia: Earlier, Nawaz et al [14] and Naqvi et al [82] demonstrated that the NRG1 genetic variant SNP rs35753505 and polymorphism8nrg433E1006 plays an important role in conferring susceptibility to SCZ in the Pakistani population and may represent a potential antipsychotic drug target in such patients [15].Moreover, Amir et al provided strong evidence that supports the role of CACNA1C, GRM3, and DRD2 genes as schizophrenia susceptibility genes in the Pakistani population [74].