APLN and alcohol dependence: KEGG pathway analysis showed PN's therapeutic effect involves various pathways such as PI3K-Akt pathway, Neuroactive ligand-receptor interaction, Rap1 signaling pathway, proteoglycans in cancer, calcium signaling pathway, focal adhesion, oocyte meiosis, cAMP signaling pathway, Glutamatergic synapse, Dopaminergic synapse, Apelin signaling pathway, cGMP-PKG signaling pathway, Alcoholism, Chemokine signaling pathway, Cholinergic synapse, Vascular smooth muscle contraction, and AMPK signaling pathway.