In our research, we identified another 9 pathways potentially related to PN's neuroprotective effect, including Neuroactive ligand-receptor interaction, proteoglycans in cancer, focal adhesion, oocyte meiosis, Apelin signaling pathway, Alcoholism, Chemokine signaling pathway, Cholinergic synapse, and Vascular smooth muscle contraction. Here, APLN is linked to alcohol dependence.