In our research, we identified another 9 pathways potentially related to PN's neuroprotective effect, including Neuroactive ligand-receptor interaction, proteoglycans in cancer, focal adhesion, oocyte meiosis, Apelin signaling pathway, Alcoholism, Chemokine signaling pathway, Cholinergic synapse, and Vascular smooth muscle contraction. This evidence concerns the gene APLN and alcohol drinking.