Significant upregulation pathways in the upregulation pathways were found involving mitogen-activated protein kinase signaling pathways, tuberculosis, Huntington's disease, Alzheimer's disease, oxidative phosphorylation, oxidative phosphorylation, osteoclast differentiation, etc. Significantly downregulated pathways involve ribosomes, T cell receptor signaling pathways, extracellular matrix receptor interactions, and insulin signaling pathways. The gene discussed is WNK2; the disease is early-onset autosomal dominant Alzheimer disease.