Among the 21 S100 genes, 3 (S100A1, S100A2, and S100A11) are significantly associated with the prognosis of CRC patients, and only S100A10 is significantly correlated with CRC stage and progression, suggesting that S100A1, S100A2, and S100A11 can serve as potential prognostic markers. This evidence concerns the gene S100B and colorectal carcinoma.