Epigallocatechin-3-gallate (EGCG), a potent anti-inflammatory molecule, inhibits TRAF6-associated K63 autoubiquitination to block the binding of TRAF6 and TAK1 and reduces the polyubiquitination of TAK1 phosphorylation and K48 linkages, thereby inhibiting RA symptoms in rats [82]. This evidence concerns the gene TRAF6 and rheumatoid arthritis.