A total of 193 cancers (59.6%) are identified to have high TRAF6 expression [121], including uterine fibroids [122], glioma [123], pancreatic cancer [124], breast cancer [125], glioblastoma multiforme (GBM) [126], colorectal cancer [127], and squamous cell carcinoma of head and neck (SCCHN) [128]. Here, TRAF6 is linked to familial pancreatic carcinoma.