Teng et al. analyzed the level of exosomal SOX2-OT in plasma and concluded that the level of exosomal SOX2-OT is significantly increased in lung squamous cell carcinoma patients compared to normal control individuals, indicating the strong power of exosomal SOX2-OT for detecting lung squamous cell carcinoma. The gene discussed is SOX2; the disease is squamous cell lung carcinoma.