Hence, we created a group that included JUPITER [18] (where all the participants had high-sensitivity CRP ≥ 2 mg/L), the HOPE-3 trial [20] subgroup (where all the participants had high-sensitivity CRP > 2 mg/L) [20], and TRACE RA [16] (where all the participants had inflammatory condition Rheumatoid arthritis), as shown in Supplementary Material 3 (Supplementary Table 4). The gene discussed is CRP; the disease is rheumatoid arthritis.