After a tempestuous course of 9 days in ICU, she made an eventful recovery.<h4>Discussion</h4>Lamotrigine, a chemically different newer antiepileptic, if rapidly titrated and used in conjunction with valproate can cause exfoliative dermatitis-like TEN, but at lower doses and as a monotherapy, female, post-partum, probably due to hormonal factors and strong association between HLA-B*1502 and AED (Antiepileptic drug)-induced SJS/TEN in patients of Asian ethnicity could be other contributing cause. The gene discussed is HLA-B; the disease is toxic epidermal necrolysis.