Furthermore, the knockdown of BECN1 represses system Xc- inhibitor (e.g., erastin and sulfasalazine)-induced ferroptosis but not that induced by RSL3, FIN56, or buthionine sulfoximine; conversely, the overexpression of BECN1 or the administration of the BECN1 activator peptide Tat-Beclin 1 promotes cancer cell ferroptosis in vitro and in vivo [71]. The gene discussed is BECN1; the disease is cancer.