Moreover, Wang et al. found that immunotherapy-activated CD8+ T cells release interferon gamma (IFNγ), which upregulates interferon regulatory factor 1 (IRF1) and downregulates SLC7A11 and SLC3A2 in cancer cells to promote tumor cell lipid peroxidation and sensitize tumors to ferroptosis [26]. Here, SLC7A11 is linked to cancer.