ATF4 and cancer: In cancer cells, BAP1 removes monoubiquitin from ubiquitinated H2A at lysine 119 (H2Aub) on the SLC7A11 promoter to suppress its expression in cells treated with erastin but not RSL3, and this effect does not require the transcription factors NRF2 and activating transcription factor 4 (ATF4) [89, 90].