Although the germline deletion of solute carrier family 7 member 11 (Slc7a11) is well tolerated in unstressed mice [22], Slc7a11 deficiency induces tumor-selective ferroptosis and inhibits pancreatic ductal adenocarcinoma (PDAC) growth [23]. The gene discussed is SLC7A11; the disease is pancreatic ductal adenocarcinoma.