However, PgE upregulated the level of the proapoptotic protein Bax by 8.4 folds compared to the Ctrl while it downregulated the level of the antiapoptotic protein Bcl-2 by 2 folds compared to the Ctrl in HepG2 cancer cells, and HaE increased the level of protein Bax by 5.3 folds compared to the Ctrl while it decreased the level of Bcl-2 by 1.5 folds compared to the Ctrl. The gene discussed is BCL2; the disease is cancer.