However, present in vitro anticancer effects of PgE or HaE were supported by the downregulation of CDK2, upregulation of PARP in HepG2, HCT-116, and MCF-7 cancer cells, and Bcl-2 downturn, upregulation of Bax and caspase-3, induction of G0/G1 cell cycle arrest, and induction of apoptosis at preG1 phase in HepG2 cancer cell line, while other previously investigated sea cucumber anticancer effects were supposed to be as a result of Bcl-2, STAT3, and MMP-9 downregulation [34]. This evidence concerns the gene MMP9 and cancer.