IL18 and infection: As a large multiprotein complex, inflammasome recruits pro-caspase-1 via ASC (the adaptor molecule apoptosis-associated speck-like protein containing a CARD) and then proceeds to cleave the cytokine precursors, such as pro-IL-1β and pro-IL-18, into mature IL-1β and IL-18 and finally mediates the immune responses against pathogen infection and tissue damage [9].