IL13 and asthma: On the one hand, chronic airway inflammation of asthma is due to the activated helper Th2 cells that produce interleukins, such as interleukin-4 (IL-4), interleukin-5 (IL-5), and interleukin-13 (IL-13), to activate B lymphocytes, synthesize specific immunoglobulin E, and activate mast cells and eosinophils to mediate the synthesis and release of a variety of active mediators [56].