In breast cancer, GPM6B can be used as a marker of tumor angiogenesis [16] In a study of the gynecological malignancies, namely, endometrial cancer, uterine cancer, and ovarian cancer, the expression level of Gpm6B was markedly elevated in patient tumor tissues and higher in the peripheral blood of patients than that of healthy controls [17]. This evidence concerns the gene GPM6B and endometrial cancer.