Network pharmacology analysis showed that 20 target genes were regulated by GQD in CRC, including PTGS2, CCNB1, SPP1, PLAU, MAOA, OLR1, NR3C2, HSD3B2, TNFSF15, AKR1C3, CA2, MMP1, MMP3, MMP9, IL1B, DUOX2, ABCG2, CXCL11, CXCL10, and ADH1C. The gene discussed is SPP1; the disease is colorectal carcinoma.