During myocardial ischemia and/or reperfusion, the membranes of the myocardial tissues are attacked, resulting in the release of myocardial enzymes, including cTnI, cTnT, LDH, and CK-MB (which are often regarded as the markers of myocardial injury), into the peripheral blood. The gene discussed is TNNI3; the disease is myocardial ischemia.