The present study revealed that the expression of ERS marker proteins GRP78 and CHOP in the I/R group and the DM + I/R group were markedly upregulated, demonstrating that ERS is involved in the occurrence of myocardial I/R-induced ALI, but showed no obvious differences between these groups in the current experimental background, and there seems to be no significant difference between these groups, which does not mean that no differences in injury occurred between the two groups. Here, HSPA5 is linked to diabetes mellitus.